[4] After his death, Cyriaca arranged the burial in her family catacomb cemetery, where the basilica San Lorenzo fuori le Mura now stands.

In 1488, Lorenzo de' Medici prevailed on his relative Pope Innocent VIII to name his son, Giovanni Cardinal-deacon of Santa Maria in Domnica when he was age 13,[9] although he was not allowed to wear the insignia until three years later.

In 1513, shortly before he became Pope Leo X, Cardinal de' Medici, in conjunction with Andrea Sansovino, added the facade portico with Tuscan columns and the fountain.

The facade of the basilica, attributed to Sansovino, is in the Renaissance style, and has a porch with five arches separated by travertine pilasters, with two square and one round window.

The interior of the basilica retains its 9th century plan, and consists of a nave and two lateral aisles of equal length and separated by 18 granite columns which were spolia from an ancient temple and crowned with Corinthian capitals.

The mosaics of the apse from the 9th century, were commissioned by Pope Paschal I[7] and depict Christ with two angels, and the twelve Apostles, with Moses and Elijah shown underneath.

In the semi-dome, Pope Paschal (with a square halo) sitting at the foot of the Blessed Virgin Mary, vested as a Byzantine noblewoman, seated on a throne with the Christ Child, and surrounded by a multitude of angels.