S. R. Thompson House is a historic home at New Wilmington, Lawrence County, Pennsylvania.

It was built in 1884, and is a three-story, Queen Anne style dwelling with a steep hipped roof and projecting gables.

It has irregular massing, multiple porches, five types of wood siding, and stick style decoration.

The house has been owned by Westminster College since 1945, and used for administrative offices and a women's residence.

This article about a property in Pennsylvania on the National Register of Historic Places is a stub.