It connected the cantons of Zürich and Schaffhausen, Switzerland, with the state of Baden-Württemberg, Germany.

At the end of 2015, the service was shortened from Bülach to Jestetten and the line no longer fell under the purview of ZVV, but continued to be operated by THURBO.

The service from Schaffhausen to Singen was taken over by Deutsche Bahn (and in December 2022 by SBB GmbH,[1] respectively), and the section between Bülach and Schaffhausen is now covered by ZVV service S9.

[2][3] The line ran from Bülach, in the canton of Zürich, via Schaffhausen, canton of Schaffhausen, to Singen (Hohentwiel) in Germany.

[citation needed] Media related to S22 line (Zürich S-Bahn) at Wikimedia Commons