Much of the first section of highway runs through the Moscow Flats area west of the North Canadian River.

On the northern outskirts of town, SH-50 intersects one of its spur routes, SH-50B, which connects Mooreland to Boiling Springs State Park.

SH-50 follows a due north heading in this area, paralleling Long Creek and crossing many of the intermittent streams that feed it.

After leaving the town, the road continues due north to its junction with US-64, where it terminates.

[4][5] Between January 1, 1929, and March 1, 1930, the highway was extended west along US-64, then north along a segment of old SH-1, passing through Lookout and ending at the Kansas state line.

[4] SH-50 underwent a major realignment on October 6, 1958, bypassing a gravel section with a straighter paved route.

[7][8] The highway was at its greatest extent from 1958 to 1964, when it started at its present-day southern terminus and continued all the way north to the Kansas state line.