The Cougars play their home matches on Bob Guelker Field at Ralph Korte Stadium located in the southwest corner of the SIUE campus in Edwardsville, Illinois.

It was announced on June 2, 2017, that the Cougars' men's soccer and wrestling teams would become affiliate members of the Mid-American Conference beginning in the 2018 season.

[3] On November 30, 2018, it was reported that Mario Sanchez had resigned to accept the position of director of youth development and community relations for Louisville City FC of the United Soccer League.

[6] In March 2023, the Cougars' primary conference home of the OVC announced it would launch a men's soccer league in the 2023 fall season with SIUE as one of its eight members.

In his nineteen seasons, only the first (3–3–0) was a non-winning one, and he compiled a record of 216–67–21, with fourteen appearances in the NCAA tournament (thirteen in Division I).

During the university's twelve years in the GLVC, Huneke's Cougars won six regular season titles, four conference tournaments, and received seven invitations to the NCAA Division II tournament, where they reached the Division II College Cup semifinals three times and were national runner-up in 2004.

[12] From Huneke's retirement in 2008 through the 2013 season, the program was led by Kevin Kalish, who took it both back into Division I and into competition in the Missouri Valley Conference (MVC).

Completing the regular season at 5–8–2, the Cougars entered the MVC Tournament as the #2 seed and an opening round bye at Bradley.

Then, in their school record ninth overtime game of the season, the Cougars downed Missouri State 1–0 to win SIUE's first MVC Tournament Championship and earn a spot in the NCAA Division I Men's Soccer Championship for the first time since 1982[25] and then advanced to the second round.

Brian Jones, however, departed to become the goalkeepers coach of the professional Saint Louis Football Club of the United Soccer Leagues.

[34] The news was released on November 30, 2018, that Mario Sanchez resigned to join the Louisville City FC as director of youth development and community relations for the United Soccer League team.

[5] On June 12, 2020, a month after the MAC announced the cancellation of its men's soccer tournament, MVC Commissioner Doug Elgin and SIUE Director of Athletics Tim Hall announced that SIUE men's soccer would return to the Missouri Valley Conference beginning with the 2021 season.

In defeating Incarnate Word 1-0, they earned the OVC's Automatic qualifier to the NCAA Tournament, the program's first bid in seven years.

In defeating Houston Christian 3-2 on a second overtime golden goal, they earned the OVC's Automatic qualifier to the NCAA Tournament.

[37] After losing OVC Goalkeeper of the Year Rob Gjelaj to a leg injury during pre-game warmups, the Cougars lost on a snowy afternoon at 23rd ranked Western Michigan 5-1 to finish the season 12-5-3.

[38] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.