In 2006, upon the urging of Singapore's Economic Development Board, St Joseph's Institution established an international school.

In adherence to government regulations, Elementary School enrolment is currently closed to Singapore citizens but open to all foreign students, provided the child holds a valid Dependent’s Pass (tied to the parent’s Employment Pass), Singapore Permanent Residency (Entry/Re -Entry Permit), or Immigration Exemption Order (for diplomats).

Today there are 7,000 La Salle Brothers and 75,000 lay Lasallian teachers working in 85 countries around the world, teaching 900,000 students in 1,000 Universities, Schools and Special Education Centres.

Subjects include English Language, English Literature, Maths, Additional Maths, Second Languages, Physics, Chemistry, Biology, Co-ordinated Sciences, Economics, History, Geography, Music, Drama, Design and Technology and Art.

In Grades 11 and 12, students pursue the International Baccalaureate programme where they choose a subject from each of six groups, namely: 1 – First Language; 2 – Second Language; 3 – Individuals and Societies; 4 – Experimental Sciences; 5 – Mathematics; and 6 – Music, Theatre Arts, and Visual Arts.

This is in addition to the core section of the course, which requires students to study Theory of knowledge, write an Extended Essay, and undertake Creativity, Activity, Service.

Several of the school's students have won the International Leader of Tomorrow Scholarship for studies at the University of British Columbia.

Grade 7, 8, and 9 students participate in week-long expeditions overseas: to Bintan, Indonesia, Tioman and Cameron Highlands in Malaysia, and to Krabi or Chiang Mai in Thailand.

Grade 11 students plan and implement the milestone Challenge Week, when they travel to another country to serve a charity of their choice in a self-organised group.

Additional educational trips and personal development programmes – like the National Youth Achievement Award – are also supported.