2L5I, 2L5J, 3CW1, 3PGW, 4PJO, 4PKD662520637ENSG00000104852ENSMUSG00000063511P08621Q62376NM_001009820NM_001301069NM_003089NM_009224NP_001287998NP_003080NP_033250snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein[5] that in humans is encoded by the SNRNP70 gene.

[6][7] snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome.

The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease.

[8][9] U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

[14] Antibodies towards snRNP70 are associated with mixed connective tissue disease.