After the First World War, it was entered into the Coppa Federale Siciliana, which was competed amongst the top Sicilian sides Marsala, Palermo, Messinese and Catanese.

The club's first professional appearance was in 1942, when the team ended round N of Serie C in sixth place.

Since then, Marsala has played 28 other times at the Serie C level, narrowly missing promotion to Serie B in 1960 (second placed in round C) and launching several young players who then obtained notoriety even at the worldwide level, such as Marco Materazzi and Patrice Evra.

A new team, Associazione Sportiva Marsala 2000, was founded as a relocation of the existing Eccellenza club Don Bosco Partinico.

[1][2] In 2008–09, Marsala 1912 won promotion to Eccellenza through play-offs, after defeating Palermo-based club Sporting Arenella in the final, so they played in the Italian 6th tier the following season.