[4] Located near Race Course ground and the Victoria Memorial Hall of Kolkata, its location is in the heart of Kolkata surrounded by cultural and historical landmarks like the Nandan complex, Rabindra Sadan, Academy of Fine Arts the Saint Paul's Cathedral, the Red Road and the Indian Museum.

The Presidency General Hospital was established near the St. John's Church (presently, in 1, Garstin Place and in its adjoining areas) which was in famous as a hellish side.

[clarification needed] According to Mrs. Bleshinden, "It was a veritable death-trap to those unfortunate who were driven to seek its shelter and had been the subject of constant complaint for years.

This house with various alterations and additions, including two other buildings created in 1795 remained in us as the Presidency General Hospital".

It is mentioned in the book "The handbook of travellers in India, Pakistan, Nepal, Bangladesh & Sri Lanka" by L. F. Rushbrook Williams that, "On the Lower Circular Road, South of Victoria Memorial is the Presidency General Hospital (1768), formerly intended for Europeans.

[7] From this record, it is quite evident that PG Hospital is a part, of world heritage, I am thankful to Calcutta Municipal Corporation and the Govt.

[8] Sir Ronald Ross made his epoch-making-discovery of "Cycle of Malarial Parasite" in this hospital and was awarded Nobel Prize in Medicine and Physiology on 10 Dec 1902.

[9] He also received the Barkley Bronze Memorial Medal from Asiatic Society, Calcutta on 20 May 1903, Sir Ronald Ross is the first Indian (born at Almorah) Nobel laureate.

After his retirement from service on 31 July 1899, he visited PG Hospital in January 1927, when the "Gate of Commemoration" bearing his statue and poem in the plaque was unveiled by Lord Lytton.

[12] The erstwhile Chief minister, Hon'ble Jyoti Basu had pledged his body to the advancement of medical science.

[13] In 2015, MCI threatened to scrap the DM-Neonatology course due to lack of qualified faculty members for teaching the subject.

[14] In 2015 an influential Trinamool Congress leader & State Medical Council President Dr. Nirmal Maji's request, Dr Pradip Kumar Mitra, a former director of IPGMER Kolkata agreed to perform hemo-dialysis on the pet dog.

[19] In July 2023, the institution took an initiative called Medimpact to provide free online access to teaching sessions of faculty members attached with IPGMER-Kolkata, for medical students from across the globe.

[22] One end of the premises contains various outpatient departments, wards and clinics, while the other comprises the administrative and college buildings for medical and paramedical students.

[25][26] On 2019, Chief Minister Mamata Banerjee inaugurated a 244-bed level-1 Trauma Care Centre at IPGMER & SSKM Hospital.

Chemotherapy for breast, lung, head and neck, cervical cancer is being given at the day-care center of the police hospital.

SSKM has been working with Mumbai's Tata Memorial Hospital for the last two years to develop state-of-the-art cancer treatment facilities in the state.

In December 2021, Department by Surgical Gastroenterology led by Dr Abhijit Chowdhury, Dr.Sukanta Ray, Dr. Somak Das and Dr Tuhin Subhra Mandal conducted a liver transplant with its own team of doctors for the first time since the state-run hospital began liver transplant in 2009.

[35] In January 2023, IPGMER's Department of Endocrinology has developed a non-invasive diagnostic test that can detect if a thyroid tumour is malignant or benign.