The story focuses on Yūta Hibiki, an amnesiac first-year high school student living in the fictional Japanese city of Tsutsujidai.

He meets the Hyper Agent Gridman in an old computer, who states that the boy has a mission he must fulfill; Yūta sets out to find the meaning to those words and his memory loss.

SSSS.Gridman was announced during Studio Trigger's panel at Anime Expo 2017, alongside Darling in the Franxx and Promare.

A special video featuring director Akira Amemiya was shown, emphasizing the story "would focus on the youth of Japan and their relationship to technology".

[17] During their Anime Expo 2018 panel, Funimation announced they licensed the series for streaming on FunimationNow and an English dub.

[18] The anime was also licensed by Funimation in the United Kingdom, Ireland, South Africa, Australia, New Zealand, Denmark, Iceland, Norway and Sweden.

[21] On November 15, 2020, it was announced during an Adult Swim YouTube livestream panel that the anime's English dub would premiere on the network's Toonami programming block on January 17, 2021.

[33] On July 9, 2020, the planned manga spin-off adaptation by Shun Kazakami was cancelled due to creative differences.