SS Equipoise was a Panamanian Cargo ship that was torpedoed by the German submarine U-160 in the Atlantic Ocean 60 nautical miles (110 km) south east of Cape Henry, Virginia, United States on 27 March 1942.

Equipoise was launched on 27 December 1905 and completed on 16 March 1906 at the Barclay, Curle & Co. Ltd. shipyard in Glasgow, Scotland, United Kingdom.

[2] Equipoise was travelling unescorted from Rio de Janeiro, Brazil to Baltimore, United States while carrying a cargo of 8000 tons of Manganese ore when on 27 March 1942 at 02.38 am, she was hit by a torpedo from the German submarine U-160 in the Atlantic Ocean 60 nautical miles (110 km) south east of Cape Henry, Virginia, United States.

[3] The seriously injured captain died shortly after the sinking on board the lifeboat and was buried at sea, which made the third mate the only surviving officer of the ship.

The 13 survivors were rescued two days after the sinking by USS Greer and brought to Norfolk Naval Base.