SS James A. Wetmore was a Liberty ship built in the United States during World War II.

She was named after James A. Wetmore, the Acting Supervising Architect of the United States, from 1915–1933.

James A. Wetmore was laid down on 14 August 1943, under a Maritime Commission (MARCOM) contract, MC hull 1502, by J.A.

Jones Construction, Brunswick, Georgia, and launched on 30 October 1943.

On 29 May 1948, she was laid up in the National Defense Reserve Fleet in Wilmington, North Carolina.