The SS Meriwether Lewis (Hull Number 170) was a Liberty ship built in the United States during World War II.

She was operated by the American Mail Line under charter with the Maritime Commission and War Shipping Administration.

On February 7, 1943, the ship left New York as part of convoy HX 227, "bound for the United Kingdom and then to Murmansk, Russia.

"[2] According to the German Navy, in the early morning of March 2, she was identified as a straggler separated from her convoy; an initial attack by U-759 failed due to engine problems.

By the time USCGC Ingham arrived at the site of the attack, all that was found was a 30-mile line of floating tires.