SS Sant′ Anna was a transatlantic ocean liner converted into a troopship in 1915, torpedoed and sunk in the Mediterranean Sea on 11 May 1918 with 605 casualties.

The ship was operational between 1912 and 1915, when she was requisitioned by the French Army and refitted as a troopship for use in World War I.

On 12 April 1916 Sant′ Anna made her first trip to the Salonika front with 1,027 Serbian Army soldiers and 129 horses on board.

She was torpedoed at 3:15 AM by the Imperial German Navy submarine SM UC-54, commanded by Heinrich XXXVII Prinz Reuß zu Köstritz.

She sank at 3:58 AM off the coast of French Tunisia, some 26 nautical miles east of Cape Bon, killing 605 of the soldiers.