SS William Grayson was a Liberty ship built in the United States during World War II.

She was named after William Grayson, a soldier, lawyer, and statesman from Virginia.

He was one of the first two US Senators from Virginia, and belonged to the Anti-Federalist faction, he was also the first member of the United States Congress to die while holding office.

William Grayson was laid down on 16 July 1942, under a Maritime Commission (MARCOM) contract, MCE hull 310, by the Bethlehem-Fairfield Shipyard, Baltimore, Maryland; she was sponsored by Mrs. Albert W. Kabernagel, the wife of the chief inspector at Bethlehem-Fairfield Shipyard, and was launched on 31 August 1942.

[5] After leaving New York City, William Grayson was involved in a collision that damaged her hull.