She has also appeared in biographical film Manto (2015), romantic comedy Lahore Se Aagey (2016), and the Indian Hindi-language educational drama Hindi Medium (2017), for which she received a nomination of Filmfare Award for Best Actress.

In addition to acting, Qamar is involved with several humanitarian causes and is vocal about issues faced by women and children and participated in concert tours and stage shows.

Later that year she appeared as model for Abrar-ul-Haq music video Boliyan from the award winning album Nachan Main Audhay Naal.

Qamar later portrayed the role of Sana Hamdani in her first and only lead appearance opposite Fawad Khan in telefim Kal aired on PTV.

In 2007, Qamar appeared in two major ATV's serials Khuda Gawah which was the remake of 1992 Indian film of the same name and Muhabbat Ab Nahi Hogi.

Later that year Qamar appeared in series of comedy dramas including Aaj TV's Mirch Masala with Veena Malik and Shamil Khan and PTV's Unbiyaanable, Maamo and No.1.

Her role in social drama Bint-e-Adam was of a rich brat who falls for a boy from a poor background, played by Ahsan Khan and marries him against her cruel father's wishes.

In 2010, she appeared in a supporting role of Surraya in Hum TV's pre partition television series Dastaan, an adaptation of Razia Butt's novel Bano.

[7][8] She then played lead role of Pooja Mohan Das in Indus Vision's partition based drama Kanpur Se Katas Tak.

Qamar then appeared in Sarmad Khoosat's romantic series Pani Jaisa Piyar (2011), where she played the character of Sana who has been engaged to Adarsh, the son of her mother's best friend ever since she was a child.

[7][17][18] That same year, Qamar collaborated with Sami Khan in two projects, Jo Chale To Jaan Se Guzar Gaye and Main Chand Si receiving further praise.

Qamar next appeared in Ameen Iqbal's Thakan (2012), where she played the role of Sadaf who works extremely hard like a machine day and night to run her family but no one except her grandfather feels sympathy for her or even cares about her.

It was followed by the leading roles in the Amna Nawaz Khan-written Na Kaho Tum Mere Nahi (2012) and Faiza Iftikhar's Yahan Pyar Nahin Hai (2012)[14][18][23] The later of which earned her a nomination for Best Actress at Hum Awards.

She gained recognition for portraying a range of characters in the serials like Shikwa Na Shikayat (2012), Shehryar Shehzadi[5] (2012), special appearance in ARY Digital's Timmy G (2012), Kaash Aisa Ho[5] (2013), Miss Fire (2013), Sannata[24] (2013), and Ullu Baraye Farokht Nahi[25] (2013), some of which garnered her several best actress nominations.

[7] After two consecutive years of poorly received serials, Qamar's career prospects began to improve in 2014; she appeared in six projects: Jaanam, Bay Emaan Mohabbat, Na Katro Pankh Mere in her first time pairing with Danish Taimoor, Bunty I Love You, Izteraab, and Digest Writer.

[14][29][30] The romantic drama Jaanam (alongside Adnan Siddiqui) and the romance Bay Emaan Mohabbat (alongside Agha Ali and Adnan Shah Tipu) earned little praise, but the family drama Bunty I Love You (a story about a girl who got married aged 17 to a much older man, later dreams of living a free life after his death) was Qamar's first critical success since Maat.

Her performance as the working women did not go well and despite the strong cast, story, production house and promotions, the drama turned out to be a major critical and commercial Disaster.

[33] She then starred alongside Adeel Chaudhry in Fahim Burney's directorial Kaisay Tum Se Kahoon which tells the story of star-crossed lovers who are reincarnated.

[19][36] The following year, Qamar collaborated with Mikaal Zulfiqar for the third time (alongside Zahid Ahmed, Kiran Haq, and Sonia Mishal) in Kashif Nisar's Sangat where she played a role of Aisha, a rape survivor who faced difficulties when her husband came to know that he was not the biological father of a daughter they have.

[59] In a scathing review, Sreehari Nair of Rediff.com labelled the film "fascinatingly frustrating" and called Qamar "natural actress, sexual daring".

Neeha of The Nation wrote, "Without a doubt, Qamar has done an outstanding job",[67] whereas reviewer from The Express Tribune said she "slayed the social media star with such finesse".

In the same year Qamar appeared as model for Abrar-ul-Haq's and Mustafa Zahid's music videos Begum Shak Karti Hai and Chingaariyan respectively.

[79][80][81] She later received praise for portraying Maya Nisar in ARY Digital's hit crime thriller Fraud collaborating with Ahsan Khan and Mikaal Zulfiqar.

In the same year Qamar made her OTT debut with Zee5 critical and commercially successful web series Mrs and Mr Shameem and Urduflix Original Naina Ki Sharafat.

[citation needed] In 2023, Qamar potrayed taxi driver Rania in short series Sar-e-Rah winning Best Actress award by USAID.

She received widespread acclaim for playing antagonist Gul Meher in Express Entertainment's mini-series Gunah directed by Adnan Sarwar opposite Juggan Kazim, Rabia Butt and Sarmad Khoosat.

[84] In 2025, Qamar made her Hum TV comeback after seven years with Saife Hassan's directorial telefilm Mohabbat Youn Bhi Honi Thi opposite Ahsan Khan.

[86] In 2009, Qamar joined the political satire show Hum Sab Umeed Se Hain, as a host and presenter where she also did the parody of politicians and actors.

[105] In August 2018, Qamar expressed in an interview, "I encourage and urge people to invest in good education as it will shape the future of our children and our society".

[7] In April 2020, she started her YouTube channel and released mini series Isolation based on the situation of Lockdown due to COVID-19[106] following The Chay Show,[107]Chaska News,[108] Kab Samjho Gay,[109] Breaking The Stereotype,[110] Music video Ek Adhuri Love Story: Chingariyan with Mustafa Zahid,[111] Eid 2023 special Eid Ka Din,[112][113] Khala Ki Jaan and Jins.