Mazo was born in Medellín, Colombia, but moved with her family to Florida, United States, as a baby.
[6] Without any preceding interest in martial arts, Mazo begun training Brazilian jiu-jitsu in Colombia at the age of fifteen.
[6] Sabina Mazo was the two time Legacy Fighting Alliance flyweight champion[7][8] and amassed a record of 6–0 prior to the signing by the UFC.
[9] Sabina Mazo made her promotional debut against Maryna Moroz on March 30, 2019, at UFC on ESPN 2.
[17] Mazo faced Alexis Davis in a bantamweight bout on February 27, 2021, at UFC Fight Night 186.