Sabine Katharina Weiss (born 26 May 1958) is a German lawyer and politician of the Christian Democratic Union (CDU) who has been serving as a member of the Bundestag from the state of North Rhine-Westphalia since 2009.

In the negotiations to form a Grand Coalition of Chancellor Angela Merkel's Christian Democrats (CDU together with the Bavarian CSU) and the SPD following the 2013 federal elections, Weiss was part of the CDU/CSU delegation in the working group on families, women and equality, led by Annette Widmann-Mauz and Manuela Schwesig.

In the coalition talks following the 2017 federal elections, Weiss was part of the working group on social affairs, this time led Andrea Nahles, Karl-Josef Laumann and Barbara Stamm.

From 2018 until 2021, she served (alongside Thomas Gebhart) as one of two Parliamentary State Secretaries to the Federal Minister for Health Jens Spahn.

[6] In January 2025, Weiss was one of 12 CDU lawmakers who opted not to back a draft law on tightening immigration policy sponsored by their own leader Friedrich Merz, who had pushed for the law despite warnings from party colleagues that he risked being tarnished with the charge of voting alongside the far-right Alternative for Germany.