Other important cities include Ciudad Vieja and San Lucas Sacatepéquez, which also hosts a marketplace and is a culinary attraction.

The Chajoma were a group of indigenous people who were Kaqchikel speaking Maya, they identified Mixco Viejo as their capital, and spread throughout the Sacatepequez Department until their capital was moved to Ciudad Vieja, in Antigua.

The southern area, which is closer to Guatemala City, has the largest population.

The southern area of the department produces coffee, sugar, tobacco, and cotton.

[7] Sacatepéquez is also home to the National Museum of Guatemalan Art, which is located in Antigua Guatemala.