A small chapel, built around 1850,[3] was used by the original East Indian villagers who were served by the St. Andrews Church in Bandra.

Every Sunday a priest from Bandra would come to Santacruz and offer mass for Catholics residing in the traditional Gaothans (village).

In the early twentieth century, many Catholics from Goa, Mangalore and Kerala began migrating to Bombay.

These people settled in Santacruz since Bombay's traditional catholic localities like Colaba and Byculla were overcrowded.

The Sacred Heart Church was completed in 1936 to cater to the spiritual needs of this growing population.