The 2010 Sacrifice was a professional wrestling pay-per-view event produced by Total Nonstop Action Wrestling (TNA), which took place on May 16, 2010 at the TNA Impact!

In the main event, Rob Van Dam defeated AJ Styles to retain the TNA World Heavyweight Championship.

In other prominent matches, Sting defeated Jeff Jarrett, Jeff Hardy defeated Mr. Anderson, and in the opening contest, The Motor City Machine Guns (Alex Shelley and Chris Sabin) defeated Beer Money, Inc. (James Storm and Robert Roode) and Team 3D (Brother Devon and Brother Ray) to determine the #1 contenders to the TNA World Tag Team Championship.

Sacrifice featured nine professional wrestling matches that involved different wrestlers from pre-existing scripted feuds and storylines.

Wrestlers portrayed villains, heroes, or less distinguishable characters in the scripted events that built tension and culminated in a wrestling match or series of matches.