Combining dance, eurodance, nü-disco and pop music, the song explores the desire to live a love and the pursuit of a man's attention.

[3][4] Subsequently on March 5, Warner released "Sacrifice" for digital download and streaming as the second single from Rexha's second studio album Better Mistakes (2021).

In her critique for The Forty-Five, Kate French-Morris highlighted it as the standout song on the album, citing its compelling qualities and noting its distinctive "Real McCoy-style" rap outro.

[9] Jon Caramanica from The New York Times observed Rexha adopting a "whispering diva" persona and similarly recognising the inspiration of German group Real McCoy's single "Another Night" (1993).

[13] In a review for Equate, the writer commended Rexha's "shimmering" vocal delivery, highlighting the instrumental arrangement, and noting the song's potential to captivate both club audiences and the main stage of Coachella.

[30][31][32] Rexha plays a bloodthirsty vampire leading a group of women as they navigate through a hospital rampage and indulge within a Blade-inspired club setting, marked by cascading blood from the roof.

[6] The video narrative commences with a sequence depicting an injured and restrained man coupled with Rexha's authoritative presence as she approaches and delivers a performance in close proximity to the captive individual.

[28][33] Leticia Romero from Radiotelevisión Española (RTVE) highlighted the video's aesthetic and its evocation of a domina-styled artist accompanied by a group of vampiric women, collectively portraying a narrative of a blood-stained mission involving the act of "sacrificing a man".