He was the vice chairman of the Bangladesh Nationalist Party and was President of undivided Dhaka city BNP for longest period of the organisation's existence.

After Bangladesh Nationalist Party's victory in 2001, Khoka was made Cabinet Minister of Fisheries and Livestock.

[9] In response, Detective Branch police raided the houses of Sadeque Hossain Khoka and Bangladesh Jatiya Party chairman Andaleeve Rahman Partha.

His eldest son Ishraque Hossain is a politician and Bangladesh Nationalist Party candidate in 2018 Mayoral election in Dhaka.

His daughter Sarika Sadeque is married to Ahmed Iftekhar, Son of Ahmad Nazir, Ex Parliament Member.