Safa Aissaoui (also Issaoui; born 23 January 1985) is a retired Tunisian middle- and long-distance runner who mostly specialized in the 800 and 1500 metres.

In her early career she won the silver medal at the 3000 metres at the 2004 World Junior Championships.

She also competed in the 5000 metres without finishing the race; in the 1500 metres at the 2003 World Youth Championships and in the junior races at the 2003 and 2004 World Cross Country Championships.

[1] At the senior level, she competed at the World Cross Country Championships in 2005, 2009, 2010 and 2011 with her best placement being 54th in 2011.

[1] In regional and continental events, Aissaoui won a silver medal in the 5000 metres at the 2004 Pan Arab Games, two silver medals (and a bronze in the relay) at the 2005 Arab Athletics Championships, and a silver medal in the 1500 metres at the 2006 African Championships.