It was in 1840 that the first settlers, most of whom came from Rivière-du-Loup, Saint-Arsène and Isle-Verte, settled on the territory of the future municipality.

As early as 1842, a mission provided religious assistance to the few inhabitants, who founded a parish under the name of Saint-Épiphane in 1863, canonically erected in 1870.

In 1873, Viger lost a small part of its territory for the creation of the municipality of Saint-François-Xavier (which would be dissolved in 1892).

In 1950, Saint-Épiphane lost another small part of its territory when Saint-François-Xavier-de-Viger was created.

In the past, the Wolastoqiyik, Amerindians close to the Mi'kmaq, lived on a reserve near Saint-Épiphane.