Saint-Alexis-de-Matapédia (French pronunciation: [sɛ̃t‿alɛksi də matapedja]) is a village and municipality in the Gaspésie–Îles-de-la-Madeleine region of eastern Quebec, Canada.

In addition to Saint-Alexis-de-Matapédia itself, the municipality also includes the communities of Léonard-de-Matapédia and Saint-Benoît-de-Matapédia.

Its name comes from Alexis Mailloux (1801-1877), a Roman Catholic vicar general who presided over the founding of the parish, and from the Matapedia river and township, in turn from the Mi'kmaq word matapegiag, meaning "river which forks".

Its first inhabitants were Acadians from Rustico, Prince Edward Island, who arrived around 1860.

[1] The local post office opened in 1866 under the name Avignon, but was renamed to Saint-Alexis-de-Matapédia in 1922.