Saint-André-de-Cubzac (French pronunciation: [sɛ̃t‿ɑ̃dʁe də kybzak], literally Saint Andrew of Cubzac; Occitan: Sent Andreus de Cubzac, Gascon: Sent Andriu de Cubzac) is a commune in the Gironde department, Nouvelle-Aquitaine, southwestern France.

Its inhabitants are called Cubzaguais in French.

Jacques-Yves Cousteau (1910–1997) was born in Saint-André-de-Cubzac and is buried in the Cousteau family plot.

It is also the birthplace of Jean Marie Antoine de Lanessan.

This Gironde geographical article is a stub.