Saint-Charles-Borromée (French pronunciation: [sɛ̃ ʃaʁl bɔʁɔme]) (2021 Population 15,285) is a city in southwest-central Quebec, Canada, on the l'Assomption River.

In Joliette Regional County Municipality, Saint-Charles-Borromée has the Maison Antoine-Lacombe, a heritage home that hosts many exhibits throughout the year.

The town is also home to the Centre Saint-Jean-Bosco, which annually hosts the Mémoires et Racines Festival of folk music from various countries and Quebec.

Two years later was founded the parish municipality of Saint-Charles-Borromée-du-Village-d'Industrie from Joliette, which decided to separate from the rest of the town in 1864 and was first named L'Industrie.

In 1957, the south of Saint-Charles-Borromée decided to also separate itself and became the parish municipality of Saint-Charles-Borromée-Sud, which later merged with Joliette and became known with the name of "Quartier Base-de-Roc" and "Carrefour du Vieux-Moulin".

The town became the municipality of Saint-Charles-Borromée in 1986 because Barthélemy Joliette's wife, Marie-Charlotte Tarieu Taillant de Lanaudière, had been largely implied with the construction of the local church.