Saint-Florentin (French pronunciation: [sɛ̃ flɔʁɑ̃tɛ̃]) is a commune in the Yonne department in Bourgogne-Franche-Comté in north-central France.

It lies at the confluence of the rivers Armançon and Armance, and on the Canal de Bourgogne.

Saint-Florentin is twinned with Zeltingen-Rachtig, Rhineland-Palatinate, Germany.

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