Saint-François-d'Assise (French pronunciation: [sɛ̃ fʁɑ̃swa dasiz]) is a municipality in Quebec, Canada.

In addition to Saint-François-d'Assise itself, the municipality also includes the communities of L'Immaculée-Conception, Saint-Jean-de-Matapédia, and Saint-Joseph-de-Matapédia.

It was renamed to Saint-François-d'Assise or Saint-François-de-Matapédia in 1889 by Joseph-Elzéar Pelletier, priest of Saint-Alexis-de-Matapédia, after François Cinq-Mars (1847-1902), who served as priest at the mission from 1890 to 1892, while also honouring Francis of Assisi.

[1] In 1968, it lost part of its territory when the Municipality of L'Ascension-de-Patapédia was created.

[1] List of former mayors: Media related to Saint-François-d'Assise, Quebec at Wikimedia Commons