Saint-Gence (French pronunciation: [sɛ̃ ʒɑ̃s]; Occitan: Sent Gençan) is a commune in the Haute-Vienne department in the Nouvelle-Aquitaine region in west-central France.

Inhabitants are known as Saint-Gençois in French.

There is an annual food and wine festival in Saint-Gence, La Vinigast.

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