Saint-Gilles (French pronunciation: [sɛ̃ ʒil]; Provençal: Sant Geli; English: St. Giles) or Saint-Gilles-du-Gard is a commune in the Gard department in southern France.

The commune formed around the nucleus of the abbey, which was the first stopping point for pilgrims bound for Santiago de Compostela in Spain, who were following the via Tolosana that led from Arles to Toulouse and crossed the Pyrenees to join other routes at Puente La Reina, thence to Santiago along the Via Compostelana.

The former abbey church was listed in 1998 among the UNESCO World Heritage Sites, as part of the Routes of Santiago de Compostela in France.

The shrine of Saint Gilles, located in the crypt of the church, is the subject of pilgrimage in particular by women wishing to become pregnant or dealing with infertility.

Saint-Gilles was the birthplace of Guy Foulques, Pope Clement IV (died 1268), whose natal house is now a museum of the archaeology, ethnology and ornithology of the Camargue.