The metro station opened on 6 October 1982 as part of the Beekkant–Saint-Guidon/Sint-Guido extension of former line 1B.

[1] Prior to the opening of an extension to Veeweyde/Veeweide on 5 July 1985, the station was the western terminus of the metro.

On 10 January 1992, a further extension from Veeweyde westwards to Bizet was opened (further extended in 2003 to Erasme/Erasmus).

Then, following the reorganisation of the Brussels Metro on 4 April 2009, it is served by the extended east–west line 5.

[2] Nearby sights include the Collegiate Church of St. Peter and St. Guido (the main church of Anderlecht, for which the station was named); Erasmus House (a museum devoted to the Dutch humanist writer and theologian Erasmus of Rotterdam);[3] the old beguinage of Anderlecht (a late medieval lay convent, now a museum dedicated to religious community life);[3] as well as Astrid Park, which is home to the Constant Vanden Stock Stadium, where R.S.C.