Saint-Léon-sur-l'Isle (French pronunciation: [sɛ̃ le.ɔ̃ syʁ lil], literally Saint Léon on the Isle; Limousin: Sent Leu d’Eila) is a commune in the Dordogne department in Nouvelle-Aquitaine in southwestern France.

Saint-Léon-sur-l'Isle station has rail connections to Bordeaux, Périgueux, Brive-la-Gaillarde and Limoges.

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