Saint-Médard-de-Guizières (French pronunciation: [sɛ̃ medaʁ də ɡizjɛʁ]) is a commune in the Gironde department, region of Nouvelle-Aquitaine, southwestern France.

It has been twinned with the village of Wedmore, England since 1975.

Saint-Médard-de-Guizières station has rail connections to Bordeaux, Périgueux, Brive-la-Gaillarde and Limoges.

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