Saint-Maime (French pronunciation: [sɛ̃ mɛm]; Occitan: Sant Maime) is a commune in the Alpes-de-Haute-Provence department in southeastern France.

The village is located on a hill at an altitude of 381 metres at the eastern extremity of the Luberon national park.

The earliest recorded population in Saint Maime were the Gaulish tribe known as the Sogiontiques who were spread through the southern Alps and had Sequester (modern day Sisteron) as their major city.

[4] The village was the location of a castle that was owned by Ramon Berenguer IV, Count of Provence and his wife Beatrice of Savoy in the 12th century.

Because of the traditional connection to these four women, there are multiple references to the 'Quatre Reinese' (Four Queens) in the village of Saint Maime and the local restaurant and hotel both carry that name.