Saint-Nicolas-de-Macherin (French pronunciation: [sɛ̃ nikɔla də maʃʁɛ̃]) is a commune in the Isère department within Auvergne-Rhône-Alpes in southeastern France.

[3] The area of the commune is 1,060 hectares and the altitude lies between 447 and 952 meters.

[10] This is low in comparison to the department unemployment rate of 10.4% for the same period.

The SITPM (Société Industrielle des Tissages Paul Merle) employs 58 people and manufactures fabrics.

The town is part of the geographical area of production and transformation of Bois de Chartreuse, the first AOC of the wood sector in France.