Saint-Paul-lès-Durance (French pronunciation: [sɛ̃ pɔl lɛ dyʁɑ̃s], literally Saint-Paul near Durance; also spelled Saint-Paul-lez-Durance; Provençal: Sant Pau de Durença) is a commune in the Bouches-du-Rhône department in Provence, southern France.

The Cadarache research center for nuclear energy is located in Saint-Paul-lès-Durance and next to it the international nuclear fusion research and engineering megaproject ITER one of the most expensive buildings ever built and the largest scientific research collaboration in history.

The town was established in the 10th century[3] and has around 1,000 inhabitants, a school, a church of the Roman Catholic Archdiocese of Aix, a 15th-century château, and a little shopping center.

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