Saint-René-de-Matane (French pronunciation: [sɛ̃ ʁəne də matan]) is a municipality in Quebec, Canada.

In addition to main population centre of Saint-René located along Quebec Route 195, the municipality also includes the communities of Le Renversé, Rivière-Matane, Ruisseau-Gagnon, and Village-à-Dancause.

[1] Saint-René-de-Matane is located on the southern slope of the St. Lawrence River, 430 kilometres (270 mi) northeast of Quebec City and 110 kilometres (68 mi) northeast of Rimouski.

This road runs along the Matane River in its section crossing the municipality.

The territory of the municipality, covering an area of 256 square kilometres (99 sq mi), also includes the Petite rivière Matane and the Gagnon stream.