Saint-Rustice (French pronunciation: [sɛ̃ ʁystis]; Occitan: Sent Rostesi) is a commune in the Haute-Garonne department in southwestern France.

Saint-Rustice is famous for its ancient Roman mosaics which were discovered in 1833.

The city takes its name from Rusticus, a bishop of Cahors, who was murdered in 630.

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