Saint-Sébastien-sur-Loire (French pronunciation: [sɛ̃ sebastjɛ̃ syʁ lwaʁ], lit.

'Saint-Sébastien on Loire'; Breton: Sant-Sebastian-an-Enk) is a commune in the Loire-Atlantique department in western France.

[3] It is the third-largest suburb of the city of Nantes, and is adjacent to it on the southeast, across the river Loire.

It has two railway stations on the line to Clisson: Saint-Sébastien-Pas-Enchantés and Saint-Sébastien-Frêne-Rond.

During the Revolution, despite its proximity to Nantes, the commune sided massively against the Republic and joined the Vendée insurrection of March 1793.