Saint-Seurin-sur-l'Isle (French pronunciation: [sɛ̃ sœʁɛ̃ syʁ lil], literally Saint Seurin on the Isle) is a commune in the Gironde department in Nouvelle-Aquitaine in southwestern France.

Saint-Seurin-sur-l'Isle station has rail connections to Bordeaux, Périgueux, Brive-la-Gaillarde and Limoges.

Marcel Berthomé was mayor from 1971 to 2020.

[3] From 2014 to 2020 he was the oldest mayor in France.

This Gironde geographical article is a stub.