Saint-Vincent-Lespinasse (French pronunciation: [sɛ̃ vɛ̃sɑ̃ lɛspinas]; Occitan: Sent Vincenç de l'Espinassa) is a commune in the Tarn-et-Garonne department in the Occitanie region in southern France.

The Barguelonne forms part of the commune's northern border.

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