Saint-Zacharie (French pronunciation: [sɛ̃ zakaʁi]; Provençal Occitan: Sant Jacariá) is a commune in the Var department in the Provence-Alpes-Côte d'Azur region in Southeastern France.

It is located within the Aix-Marseille-Provence Metropolis, on the departmental border with Bouches-du-Rhône, northeast of Aubagne.

In 2021, it had a population of 5,931.

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