St. Clare Parish was built to take over the parochial functions of the Mission Santa Clara de Asís after it burned in 1925.
It was dedicated along with the church in a ceremony where parishioners gathered in front of the mission and carried the statue in a procession across the street to the new St Clare church on August 15, 1926 (four days after the feast day of St. Clare).
The parish also assumed control of the Saint Clare School located next door and founded in 1856.
St. Clare's church celebrated its 200th anniversary on Sunday, April 17, 1977, with a 12:15 pm mass officiated by Archbishop Joseph McGucken and a reception dinner and dancing at Santa Clara's Benson Center.
St. Clare's Catholic Parish founded by the Franciscans under Father Tomas De La Pena, in 1777.