It was founded by Irish Dominican Sisters, beginning as the Bom Sucesso Girls Day School in 1954.

With the building of the bridge over the Tagus River, now called the 25 de Abril Bridge, the expanding English expatriate community asked the sisters to establish a new school.

St Dominic's College, English language co-educational school was founded in the Bom Sucesso convent.

The school started with fewer than 20 students but quickly needing more space.

In 2010 St Dominic's was sold to Veritas Educatio/SA, whose owners are Catarina Formigo, Filipe Pinhal and Joaquim Marques dos Santos.