[2] At the end of the Fall 2015 semester, Saint James moved its Bonaire operation, students, and faculty to the St. Vincent and the Grenadines campus.

[citation needed] In 2022 the FTC determined that "the school misrepresented its U.S. Medical Licensing Examination (USMLE) Step 1 pass rate in sales calls, presentations, and marketing materials.

"Saint James School of Medicine – and its Illinois-based operators – will have to pay $1.2 million toward refunds and debt cancellation for students harmed by its deceptive marketing, according to an FTC press release."

The school refuted these allegations in their statement saying that they settled to avoid lengthy and expensive legal proceeding with the FTC.

Semesters 1-5 are basic sciences completed at one of the school's two Caribbean campuses (Anguilla and St. Vincent and the Grenadines).

Starting in September 2024, all Basic Science courses work is conducted on the school's campus in St. Vincent and the Grenadines.. After completion, students are expected to complete the United States Medical Licensing Exam (USMLE) Step 1, for which the school offers a pass guarantee.

In July 2015, CAAM-HP extended Saint James' Anguilla campus' initial provisional accreditation with probation for one year, until 2016.

The Anguilla campus' CAAM-HP initial provisional accreditation with probation was extended for one year in July 2016.