Saint Joseph's Roman Catholic College for Boys, also known as Saint Joseph's High School, is a historic school building at 760 Merrimack Street in Lowell, Massachusetts.

The three-story brick Romanesque Revival building was built in 1892 to a design by Irish-American church architect Patrick W. Ford.

The school was one of a number of Roman Catholic institutions built to serve Lowell's burgeoning French-American community, a significant portion of which had settled in "The Acre", as the neighborhood is known.

The diocese sold the building in 1997 to a local nonprofit, which converted it to residential use.

This article about a National Register of Historic Places property in Lowell, Massachusetts is a stub.