[4] Notable creole author and educator Alexander Dimitry is buried at Saint Louis Cemetery Number One.

The cemetery inspired an Alkemia Perfumes' scent of the same name, which is described as "An atmospheric brooding of Spanish moss, crumbling stone, old cement, red clay brick, and graveyard dirt.

"[5] The renowned Voodoo priestess Marie Laveau is believed to be interred in the Glapion family crypt.

Other notable New Orleanians here include Bernard de Marigny, the French-Creole aristocrat and politician who founded both the Faubourg Marigny and Mandeville, Louisiana; Barthelemy Lafon, the architect and surveyor who allegedly became one of Jean Lafitte's pirates; and Paul Morphy, one of the earliest world champions of chess.

Effective March 1, 2015, the Roman Catholic Archdiocese of New Orleans, which owns and manages this cemetery, has closed it to the general public, ostensibly because of the rise in vandalism there.

However, in a controversial move, the diocese is now charging tour companies for access ($4,500 per year, or lesser amounts for short periods).

A number of notable jazz and rhythm & blues musicians are buried here, including Danny Barker and Ernie K-Doe.

These include the Venerable Mother Henriette DeLille, who is a candidate for sainthood by the Catholic Church, Rodolphe Desdunes (1849–1928) and Jean Baptiste Dupeire (1795–1874) prominent citizen of New Orleans, among others.

3 is located approximately 2 miles (3.2 km) away from the French Quarter, some 30 blocks from the Mississippi River, fronting Esplanade Avenue near Bayou St. John.

The crypts on average are more elaborate than at the other St. Louis cemeteries, including a number of fine 19th century marble tombs.

Those entombed include ragtime composer Paul Sarebresole, photographer E. J. Bellocq, and painter Ralston Crawford.