St. Luke's Home for Destitute and Aged Women was incorporated by an act of the Connecticut State Assembly on June 22, 1865.

Two bay window piers flank the front entrance, capped off above the roof line by gable-roofed dormers.

Decorative elements such as the wrought iron fence, ivy on the facade, and quoin-like brick projections on all corners add a picturesque quality to the building.

[2] The large brick institutional building dominates the area by its mass and corner siting at Pearl and Lincoln Streets in Middletown's residential North End.

It forms a dividing line between large structures to the south towards Washington Street and more modest late Victorian era worker homes to the north.